Methylsulfonylmethane, more commonly known as MSM, is a sulfur compound found naturally in animals, humans, and many plants. MSM is commonly produced in a lab and often combined with other ingredients such as glucosamine or chondroitin.
MSM has been shown to reduce inflammation and improve other OA symptoms such as joint stiffness. Participants in several studies reported overall improvement in physical function. Animal studies have shown that it can also inhibit the breakdown of cartilage. Other studies have shown that MSM used in combination with other supplements such as glucosamine, chondroitin, and boswellia is more effective than when used alone.
The recommended dosage for MSM is 1000mg to 3000mg daily. It is best to take with meals to avoid stomach upset.
Possible side effects are abdominal discomfort, diarrhea, and headache. As with most supplements, avoid if you are pregnant or breastfeeding. Talk to your doctor before taking if you take blood thinners. Do not take if you are allergic to sulfa.